[CitizensTruth] fluvaccine and nerve cells (2)

[Kris Knight]

>

> Here is the second installment of this review, which looks at the  

> role of endotoxins contained in vaccines either as contaminants or  

> in the adjuvant material, and the potential synergistic effects of  

> endotoxins, adjuvants, and HA in activity against nerve cells.

>

> There is also an interesting discussion at the fluwiki link on this  

> material, which is not included here.  Also, you'll need to go to  

> that link to access the charts and the other hotlinks.

>

> Char

> _______________________

>

> http://www.newfluwiki2.com/diary/3625/guillainbarre-syndrome-after-influenza-vaccination-more-lessons-from-1976

>

> Guillain-Barre Syndrome after Influenza Vaccination - More Lessons  

> from 1976

>

> by: SusanC

>

> Mon Jul 27, 2009 at 19:45:18 PM EDT

>

> A follow-up to Swine Flu 1976 - Old Vaccines, New Lessons?

> SusanC :: Guillain-Barre Syndrome after Influenza Vaccination - More  

> Lessons from 1976

> The 1976 vaccine was correlated with an increased incidence of GBS,  

> which, according to a recent study described earlier, may be due to  

> molecular mimicry, between the HA molecule and human gangliosides,  

> proteins that permeate our nervous system.

> Ideally one would want to repeat the study and confirm the findings,  

> at least, but we are in a pandemic, and tptb are in a rush to  

> provide vaccines for millions of people.  In the absence of further  

> data, is there anything we can learn, even tentatively?

>

>

> If HA is indeed a biological mimic, it could account for the very  

> small but increased incidence of GBS after flu vaccines in general,  

> and the 1976 one in particular.  The effect of biological mimicry  

> is, by definition, dependent on how closely the molecules are  

> similar.  To the extent that different HAs from different flu  

> viruses have slight differences in conformation, they would probably  

> have varying degrees of mimicry, such that vaccines made from these  

> HAs may therefore have varying ability to induce GBS.  Which is  

> compatible with the varying incidence of GBS reported after seasonal  

> flu vaccinations in different years.  (see Haber 2004, Guillain- 

> Barré Syndrome Following Influenza Vaccination)

> As an extension of that, can we also say that any HA that is similar  

> to 1976 (like the current H1N1) may be more likely to induce GBS?   

> We can't answer that question, because we don't know what other  

> components are/were important in the pathogenesis of GBS in 1976.

>

> For example, it was widely believed that the 1976 vaccine had a  

> particularly high endotoxin content, a bacterial by-product (or  

> impurity) of the vaccine manufacturing process, which may have  

> contributed to the higher GBS rate.

>

> One very interesting study Geier 2003, Influenza vaccination and  

> Guillain Barre syndrome had the following findings:

>

>

> increased risk of acute GBS and severe GBS after influenza  

> vaccination as compared to adult tetanus-diphtheria (Td) vaccine -  

> which was chosen as control since an IOM review concluded "the  

> evidence favored a causal relationship" between GBS and Td  

> vaccination.

>

> Influenza vaccines contained from a 125- to a 1250-fold increase in  

> endotoxin concentrations in comparison to an adult Td vaccine control

>

> Endotoxin concentrations varied up to 10-fold among different lots  

> and manufacturers of influenza vaccines, as shown in the chart

>  [see chart at above fluwiki link]

>

>

> There was statistically significant variation in the incidence of  

> reported GBS after vaccination from vaccines from the different  

> manufacturers.  Unfortunately, the identity of specific  

> manufacturers for this test could not be revealed, as the CDC deemed  

> this information to be 'proprietary and confidential' ;-( , hence we  

> cannot determine from the data whether those vaccines with higher  

> endotoxin content were associated with higher GBS report rates.

> Nevertheless, the authors still concluded that

>

> The biologic mechanism for GBS following influenza vaccine may  

> involve the synergistic effects of endotoxin and vaccine-induced  

> autoimmunity.

> Here, the question gets interesting, because different kinds of  

> bacterial endotoxins, eg from E. coli, have been used as vaccine  

> adjuvants.  The intranasal flu vaccine thatcaused a spate of Bell's  

> palsy cases leading to its withdrawal, was adjuvanted with endotoxin  

> from E. coli.  The novel adjuvant AS04, made by GSK and used in  

> Hepatitis B (Fendrix) and HPV (Cervarix) vaccines in Europe, also  

> contains MPL, which, according to this paper with a rather  

> triumphant title, Vaccine adjuvants: the dream becomes real, "comes  

> from the cell wall LPS (=lipopolysaccharide) of Gram-negative  

> Salmonella minnesota R595".

>

> In other words, if endotoxin was a significant factor in vaccine- 

> induced GBS in 1976, the whole episode may have been a demonstration  

> of the effect of a naturally-occuring adjuvant on induction of  

> autoimmunity.

>

> Here's my question.  And please don't fault me for asking  

> 'rhetorical' questions - I'm asking them because they are real, I  

> don't know the answer, but the answer may be relevant to our  

> assessment of the safety of using novel adjuvants in flu vaccines in  

> the current pandemic.

>

> If endotoxin was acting as an adjuvant and was partly responsible  

> for the increased incidence of GBS in 1976, would much more powerful  

> vaccine adjuvants deliberately formulated to enhance the immune  

> response to the HA (and to a lesser degree NA), aka MF59 or AS03,  

> also enhance the biological mimicry to such a degree that the risk  

> of GBS would again be dramatically increased?  Since we (or at least  

> I) don't know the relative potency of the endotoxin content of the  

> 1976 vaccine possibly acting as adjuvant, as compared to MF59 or  

> AS03, I don't believe we can give even a rough assessment, of the  

> potential for GBS, before large scale vaccination happens, right?

>

> Does that scare you?  It does me.  Not personally, but on a  

> population level, the effect could be catastrophic.

>

> __________

>

> btw, any correlation between

> endotoxin concentration and rate of GBS being reported, is important  

> for a specific and important reason - it can potentially demonstrate  

> a dose-response relationship, which according to this (and other)  

> product liability consultancy, is a fundamental requirement for  

> making liability exposure assessment.

> Which is a good example of the kind of issues that increasingly  

> underlie major areas of scientific research...

>


Kris Knight of WellAware Life Enhancement Center
Phone:  1-608-ALL-LIFE
welaware at merr.com






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